在中国宁夏省农场动物中对多种抗生素耐药菌进行基因组鉴定
Haoyu Zhao1,2, Wen Zhang3, Tianran Tang1,2
1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest Agricultural and Forestry University, Xianyang 712100, China.
Antibiotics (Basel, Switzerland)
|November 27, 2025
概括
农场动物携带多种耐药性肠球菌,构成公共卫生风险. 这项研究突出显示了猪Enterococcus的显著耐药性和潜在的基因传播到人类.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 基因组学就是基因组学.
背景情况:
- 菌种类是抗生素耐药性基因的重要储存库.
- 越来越多的细菌耐药性需要了解Enterococcus在公共卫生威胁中的作用.
研究的目的:
- 从各种农场动物中分离出Enterococcus的抗生素耐药性概况和遗传特征.
- 为了研究抗生素耐药性基因的跨物种传播潜力.
主要方法:
- 对89个Enterococcus分离体进行了抗生素敏感性测试.
- 使用了全基因组测序和生物信息学分析.
- 隔离剂来源于宁夏自治区的,猪,牛和羊.
主要成果:
- 观察到高耐药率 (>95%) 的克林达米辛,塞福西丁,硫甲醇,和三甲.
- 96.6%的分离物表现出对多种抗生素的耐药性.
- 来自猪的肠球菌表现出显著更高的耐药性,其 optrA 基因普遍存在 (61.5%).
结论:
- 从农场动物中分离出的肠球菌表现出广泛的抗生素耐药性.
- 确定了Enterococcus的物种间传播事件.
- 这些发现强调了抗生素耐药性基因从动物传播到人类的风险.
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