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胎儿性别调节霍夫尔细胞对人类胎盘糖尿病的反应

Zdenek Tauber¹, Max Mrstik¹, Adela Burianova¹

¹Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.

|November 27, 2025

概括

孕产妇糖尿病通过减少CD206的表达和增加碎片,特别是女性胎儿,影响胎盘免疫细胞 (霍夫尔细胞). 这表明,在怀孕期间,胎儿与母亲的界面上的免疫耐受性发生了变化.

科学领域:

免疫学免疫学免疫学
生殖生物学生殖生物学
围产儿医学围产儿医学

背景情况:

霍夫尔细胞 (Hofbauer cells,简称HBCs) 是胎儿巨细胞,在胎儿与母亲的界面对免疫耐受性至关重要.
这些细胞主要表现出M2表型,由CD206表达标记.

研究的目的:

调查孕产妇糖尿病 (1型和妊娠) 和胎儿性别对霍夫尔细胞特征的影响.
评估CD206的表达,形态和胎盘小体中亡体的积累.

主要方法:

使用免疫组织化学和形态分析来量化HBC和CD206强度.
在1型糖尿病 (T1DM),妊娠期糖尿病 (GDM) 和正常血糖控制的怀孕期间的胎盘小中评估了亡体积累.
基于母亲的诊断和胎儿的性别进行了比较.

主要成果:

孕产妇糖尿病和胎儿性别显著影响了CD206强度和亡体积累,诊断和性别之间有着显著的相互作用.
从对照组到GDM和T1DM,CD206强度逐渐下降,女性的减少更为明显. 减少的CD206与改变的HBC形态和增加的IL-1β相关.
从对照对象到GDM和T1DM,亡体积累增加,在男性胎儿中观察到更高的数量.

结论:

孕产妇糖尿病与减少CD206表达,改变HBC形态和增加胎盘小中的apoptotic体有关.
这些发现表明,孕产妇糖尿病损害了胎盘免疫环境的耐受性能力.
雌性胎儿可能表现出更大的霍夫尔细胞可塑性,可能有助于形成更耐受性的胎盘环境.

关键词:

这种CD206受体是CD206受体.霍夫巴乌尔细胞是什么?在糖尿病中,糖尿病是血糖性糖尿病.胎儿性别胎儿性别形态测量法形态测量法形态测量法这是胎盘巨细胞.

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