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一个当代的多方面的叙述审查甲状腺功能障碍的人生活与人类免疫缺陷病毒的人
Mohanad Alhalabi1, Mohamed M Attian1, Lana Alhalabi2
1Faculty of Medicine and Health Sciences, University of Buckingham, Buckingham MK18 1EG, UK.
Biomedicines
|November 27, 2025
概括
接受联合抗逆转录病毒疗法 (cART) 的艾滋病毒患者甲状腺功能障碍的发生率增加,特别是亚临床甲状腺功能低下症. 建议进行监测,特别是在免疫复合期间,以有效管理这些情况.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 联合抗逆转录病毒疗法 (cART) 改善了艾滋病毒感染者 (PLWH) 的预期寿命.
- 在艾滋病毒诊所增加的监测显示,PLWH中甲状腺功能障碍的发病率正在上升.
- 甲状腺功能障碍是PLWH人群中显著的并发症.
研究的目的:
- 审查有关艾滋病毒感染者甲状腺功能障碍的文献.
- 在PLWH中确定甲状腺功能障碍的患病率和类型.
- 讨论cART,免疫复合和甲状腺疾病之间的关系.
主要方法:
- 一个主要研究,案例报告和元分析的叙述性综述.
- 在PubMed,Embase和Cochrane数据库进行文献搜索.
- 对PLWH报告的甲状腺功能障碍患病率和相关因素的分析.
主要成果:
- 亚临床甲状腺功能障碍 (SCH) 是最常见的甲状腺功能障碍,影响高达40%的PLWH严重免疫抑制 (CD4 T细胞数<350细胞/mm3).
- 过度甲状腺功能过高和甲状腺恶性瘤不太常见,但有报道.
- cART启动和免疫复合炎症综合征 (IRIS) 与甲状腺功能障碍有关,包括格雷夫病.
结论:
- 在cART的PLWH中,甲状腺功能障碍的风险增加,特别是SCH.
- 监测甲状腺功能障碍,包括格雷夫病和恶性瘤,至关重要,特别是在免疫复原期间.
- 推的查包括FT4,FT3,TSH,甲状腺抗体,以及对症状的警,特别是在患有并发症或显著免疫变化的患者中.
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