探索维生素D和VDR多形态与COVID-19和流感中的疾病严重程度的关联
Alexandru Constantin Sîrbu1, Ioana Corina Bocșan1, Octavia Sabin1
1Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hațieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Biomedicines
|November 27, 2025
概括
低维生素D水平与COVID-19和流感患者的严重程度增加有关. 维生素D受体 (VDR) 的遗传变异与疾病严重程度没有显著联系.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 像COVID-19和流感这样的呼吸道病毒感染对公众健康构成重大风险.
- 维生素D因其免疫调节特性而闻名,之前的研究表明维生素D水平与呼吸道感染严重程度之间存在联系.
- 维生素D受体 (VDR) 的遗传变异可能会影响免疫系统的反应.
研究的目的:
- 调查维生素D水平,VDR基因多态性和COVID-19和流感的临床严重程度之间的关联.
- 分析与疾病严重程度和维生素D状况相关的炎症标志物.
主要方法:
- 一项涉及2023-2024年冬季期间71名住院患者的横截面研究.
- 对血清维生素D水平的测量和对VDR多态的基因定型 (rs1544410,rs731236,rs7975232).
- 评估临床严重程度和炎症标志物 (CRP,中性粒细胞计数,淋巴细胞计数).
主要成果:
- 与中度病例和严重流感病例相比,在严重的COVID-19病例中观察到显著较低的维生素D水平.
- 严重的COVID-19患者表现出炎症标志物升高和淋巴细胞数量减少.
- 在VDR多态性和疾病严重程度或维生素D水平之间没有发现显著的关联.
结论:
- 维生素D水平可能在调节呼吸道病毒感染的严重程度方面发挥作用.
- 在这些感染中,VDR遗传多态化对疾病严重性的影响需要进一步调查.
- 需要进行额外的研究,以确定维生素D补充是否可以提高呼吸道病毒感染的临床结果.
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