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低皮质醇可以预测长期COVID吗? 一个有争议的问题.

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较低的早晨皮质醇在长期COVID (LC) 患者中很少见,大多数患者表现出正常或升高的水平. 这项研究强调考虑昼夜时间来准确解释LC中的皮质醇.

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昼夜节律 昼夜节律皮质醇是一种皮质醇.过高皮质醇主义是什么?低皮质醇主义是什么?长时间的COVID.长期COVID的生物标志物这是后急性COVID-19综合征.

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科学领域:

  • 内分泌学 在内分泌学.
  • 传染性疾病 传染性疾病
  • 神经科学是一个神经科学.

背景情况:

  • 皮质醇失调是长期COVID (LC) 的拟议生物标志物,但现有的研究表明结果不一致.
  • 之前的研究表明LC中的皮质醇较低,但收集时间和研究设计的多样性限制了结论.
  • 了解皮质醇模式对于识别潜在生物标志物和了解LC病理生理学至关重要.

研究的目的:

  • 在独立的长期COVID队列中评估早晨血清皮质醇分布.
  • 在皮质醇水平评估中考虑昼夜时间和睡眠模式.
  • 为了研究皮质醇作为长期COVID的生物标记物的实用性.

主要方法:

  • 在斯坦福长期COVID诊所对86名成年人的回顾性横截面研究.
  • 早晨血清皮质醇测量时间为05:00-10:00,分为早晨峰值 (EMP) 和中午峰值 (MMP) 窗口.
  • 分析包括联盟睡眠问卷 (ASQ) 数据和炎症标志物 (CRP,D-二次体).

主要成果:

  • 平均血清皮质醇水平为15.67±6.76μg/dL.
  • 只有1.2%的患者的皮质醇水平较低;62.8%的皮质醇水平正常,36.0%的皮质醇水平升高.
  • 皮质醇分布在EMP和MMP收集时间或睡眠对齐之间没有显著差异.

结论:

  • 与之前的报道相反,在这个长期的COVID队列中,早晨皮质醇水平较低并不常见.
  • 大多数患者呈现出正常或升高的皮质醇水平,无论采集时间如何.
  • 循环节时间对于解释长期COVID中的皮质醇至关重要;需要进一步的前性研究.