在败血和心脏性休克中评估血管度和液体平衡:关于皮肤水分流失的可行性研究作为诊断工具
Sabrina Kopp1,2, Ingo Sagoschen1, Susanne Helena Karbach1,2,3
1Department of Cardiology-Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.
Biomedicines
|November 27, 2025
概括
超皮层流失 (TEWL) 测量是可行的监测流体平衡和危急病患者的血管度. 这种非侵入性方法显示出改善重症监护病房患者评估的潜力.
科学领域:
- 临界护理医学 临界护理医学
- 生理学 生理学 生理学
- 生物医学工程 生物医学工程
背景情况:
- 冲击中的流体管理具有挑战性,评估方法不足.
- 在冲击中最佳的流体导向仍在争论中.
- 需要用于血管度的非侵入性标记物.
研究的目的:
- 调查皮层间的水损失 (TEWL),以估计液体平衡.
- 评估TEWL作为血管度的非侵入性标记物.
- 评估TEWL在机械通风患者的可行性.
主要方法:
- 在8名机械呼吸患者中进行前性可行性研究.
- 每天使用Tewameter®进行TEWL测量.
- 基于TEWL和基于配方的皮肤水分损失估计的比较.
- 通过PiCCO®技术对TEWL和系统血管阻力指数 (SVRI) 的相关性分析.
主要成果:
- 除了额头外,TEWL测量在所有身体部位上都是一致的.
- 基于TEWL的水损失估计明显低于基于配方的估计.
- 正常化的个体内TEWL与SVRI呈现负相关性,表明较高的水损失与较低的血管度.
结论:
- 在重症监护室 (ICU) 患者中,TEWL测量是可行的.
- TEWL可以提高液体平衡评估和血管度监测.
- 这种非侵入性方法可以补充当前的诊断方法,需要在更大的队列中进一步研究.
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