特殊人群中的感染:关注炎症性肠病-从发病到管理的叙述性综述
Cristina Seguiti1,2, Enrico Tettoni3,4, Edoardo Pezzuto3,4
1SS Malattie Infettive, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy.
Biomedicines
|November 27, 2025
概括
炎症性肠病 (IBD) 患者面临着显著更高的Clostridioides difficile感染 (CDI) 风险,经历更严重的结果. 有效管理IBD是预防和减少CDI复发的关键.
科学领域:
- 胃肠病学和传染病学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 艰难结肠杆菌感染 (CDI) 是炎症性肠病 (IBD) 患者的一个重要并发症.
- 与一般人群相比,IBD患者的CDI风险增加了4-5倍.
- 在IBD中,CDI与严重的疾病,更高的住院,大肠切除术,复发和死亡率有关.
研究的目的:
- 审查有关IBD中CDI的流行病学,发病因子,风险因素,诊断和管理的最新证据.
- 要突出IBD和CDI之间的复杂相互作用.
- 提供对最佳管理策略的见解.
主要方法:
- 对当前文学进行叙述性回顾.
- 对IBD患者的CDI数据的综合.
- 对致病机制和风险因素的分析.
主要成果:
- 病原发生包括失生症,改变胆酸代谢,以及炎症粘膜的易感性增加.
- 关键的危险因素包括活跃的结肠疾病,抗生素使用,住院治疗和免疫抑制疗法.
- 菲达克索米辛或万科米辛是第一线治疗方法;便微生物群移植仅用于复发病例.
结论:
- 优化IBD控制对于预防初级和复发性CDI至关重要.
- 早期识别,适当的抗生素使用和基于微生物群的策略对于改善结果至关重要.
- 解决CDI和IBD之间的相互致病相互作用对于降低医疗保健成本至关重要.
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