对周围动脉疾病的遗传洞察:叙述性审查
Nonanzit Pérez-Hernández1, José Manuel Rodríguez-Pérez1, Luis Eduardo Nicanor-Juárez1,2
1Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Biomedicines
|November 27, 2025
概括
遗传和环境因素有助于外围动脉疾病 (PAD). 本综述详细介绍了与PAD相关的遗传变异,途径和基因表达,有助于开发更好的患者干预措施.
科学领域:
- 遗传学和分子生物学
- 心血管疾病研究研究
- 病理生理学 病理生理学
背景情况:
- 周围动脉疾病 (PAD) 是一种广泛的动脉样硬化病,影响下肢动脉.
- PAD涉及复杂的遗传和环境因素,影响其发展和进展.
- 肢体血液流量减少是PAD的一个标志.
研究的目的:
- 审查与PAD斑块发作,进展和破裂相关的关键遗传变异.
- 为了确定相关的KEGG途径,涉及到PAD病原体.
- 总结PAD患者活检中的基因表达和转录组发现.
主要方法:
- 在PAD中对遗传关联研究的文献综述.
- 对相关生物过程的KEGG路径数据库的分析.
- 来自PAD患者样本的转录组数据的检查.
主要成果:
- 鉴定导致PAD的特定遗传变异.
- 某些KEGG通路与PAD病理生理学的关联.
- 来自对PAD机制的基因表达研究的见解.
结论:
- 了解遗传因素对于阐明PAD至关重要.
- 凯格路径分析为PAD分子机制提供了一个框架.
- 转录组数据为PAD表型提供了功能性见解,指导治疗开发.
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