炎症性肠病 (IBD) 中炎症的分子景观:精准医学的目标
Loris Riccardo Lopetuso1,2, Marco Murgiano2,3, Elisabetta Mantuano1
1Department of Life Sciences, Health, and Health Professions, Link Campus University, 00165 Rome, Italy.
Biomedicines
|November 27, 2025
概括
细胞衰老导致炎症,修复功能受损,以及炎症性肠道疾病 (IBD) 中的癌症风险. 针对衰老及其分泌表型 (SASP),为IBD和结直肠癌 (CRC) 的预防提供了新的治疗途径.
科学领域:
- 胃肠道学和免疫学
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),是慢性免疫媒介疾病,导致粘膜损伤和增加结肠直肠癌 (CRC) 风险.
- 在IBD中持续的炎症加快了上皮的周转,诱导了氧化应激,并重塑了组织微环境,从而导致疾病的进展和瘤.
- 细胞衰老,以衰老相关的分泌表型 (SASP) 为特征,越来越多地被认为是关键机制,在IBD中将炎症,愈合障碍,纤维化和癌症发展联系在一起.
研究的目的:
- 审查炎症,氧化应激和细胞衰老在IBD病变发生中的机制性作用.
- 批判性地评估IBD新兴的向治疗方法,重点关注解决衰老和SASP的策略.
- 提出IBD管理的未来方向,包括生物标记指导治疗和干预措施,以减轻长期的癌症风险.
主要方法:
- 关于IBD机械轴的文献综述,包括炎症,氧化应激和衰老.
- 对IBD当前和新兴治疗策略的批判性评估.
- 分析SASP在延续炎症和促进瘤中的作用.
主要成果:
- 细胞衰老,标志着特定的分子变化 (例如,p16/p21上调,端粒侵蚀) 和SASP,有助于UC的屏障功能障碍,并限制CD的再生.
- 肠道炎症的发病包括遗传因素,环境影响,肠道失调和免疫失调的复杂相互作用,衰老加剧了这些过程.
- 针对炎症的新兴疗法 (例如,抗TNFα,IL-23抑制),免疫路径 (例如,JAK抑制剂,S1P调节器) 和衰老 (老化药物,细胞疗法,微生物干预) 是有前途的.
结论:
- 细胞衰老及其SASP是IBD病原体的核心,驱动慢性炎症,损害组织修复,增加CRC风险.
- 旨在调节衰老,SASP和相关炎症途径的向疗法代表了IBD治疗和癌症预防的有希望的前沿.
- 以生物标志物为指导的治疗策略和干预措施来破坏SASP驱动的炎症循环对于改善IBD患者的长期结果至关重要.
相关概念视频
01:29Inflammatory Bowel Disease IV: Pharmacological Management
452
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
452
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
620
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
620
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
465
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
465
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
876
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
876
01:30Inflammatory Bowel Disease II: Crohn's Disease
932
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
932
01:17Chronic Bowel Disorders: Introduction
735
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
735