癌症预后的机器学习框架:通过ARIMA-CNN整合时间和免疫基因动态
Rui-Bin Lin1, Linlin Zhou2,3, Yu-Chun Lin4
1Department of Statistics and Information Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Biomedicines
|November 27, 2025
概括
这项研究引入了一种新的ARIMA-CNN模型来分析瘤免疫微环境在肝癌中的基因表达,揭示了改善生存预测和精确免疫治疗的关键免疫细胞特征.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
背景情况:
- 肝细胞癌 (HCC) 对全球健康造成重大负担,死亡率高.
- 瘤免疫微环境 (TME) 极大地影响HCC的进展和患者的结果.
- 传统的TME分析通常集中在单个基因上,忽视了复杂的免疫基因相互作用.
研究的目的:
- 为了研究化学因子 (C-C动机) 连接体5 (CCL5) 和相关免疫基因在HCC的预后价值.
- 开发和验证一种创新的自回归集成移动平均 (ARIMA) 和卷积神经网络 (CNN) 框架,用于生存分析.
- 为了比较ARIMA-CNN模型与传统预后方法的有效性.
主要方法:
- 在使用ARIMA的230名HCC患者中,对CCL5表达的时间序列分析.
- 整合ARIMA残留物和免疫基因表达数据作为CNN模型的输入.
- 使用考克斯比例危险模型,卡普兰-梅尔曲线和等级集群的预测评估.
主要成果:
- 在ARIMA-CNN框架中,比基于中位数的分层表现出优越的预后能力.
- CD8+ T 细胞和效应性 T 细胞的特征与改善的生存率显著相关 (HR:0.7324,p=0.0008).
- 一个包括B细胞,Th2细胞,T细胞和NK细胞的集群表明了保护作用 (HR:0.8714,p=0.1093).
结论:
- 这项研究介绍了第一个ARIMA-CNN基因表达和生存分析框架,整合了时间动态和机器学习.
- 这种综合性方法为HCC TME提供了更深入的见解.
- 这些发现突出了推进精密免疫疗法的潜力,并确定了用于HCC管理的新生物标志物.
关键词:
在阿里马,阿里马就是阿里马.CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5 CCL5考克斯模型 考克斯模型肝细胞癌是肝细胞癌.卡普兰梅尔和瘤免疫微环境卷积神经网络是一种卷积神经网络.生存分析,生存分析.更多相关视频
04:09Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
Published on: October 10, 2018
8.6K
06:32Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
Published on: August 18, 2023
2.8K
相关概念视频
Cancer Survival Analysis
633
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
633
Adaptive Mechanisms in Cancer Cells
6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Mouse Models of Cancer Study
6.4K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.4K
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
