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Updated: Jan 10, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
Published on: March 8, 2013
无对比辐射的NIR肺部成像,没有对比辐射.
Jiří Votruba1, Martin Drahanský2, Tomáš Goldmann3
1I. Clinic of Tuberculosis and Respiratory Diseases, General University Hospital in Prague, 128 08 Prague, Czech Republic.
这项研究引入了一种新的,无辐射的光学技术,使用近红外 (NIR) 透光来定位单独的肺结节 (SPN). 这种方法可视化肺组织,潜在地改善了没有X射线的活检指导.
科学领域:
- 肺部医学 肺部医学
- 医疗成像医学成像
- 光学物理学 光学物理学
背景情况:
- 孤独肺结节 (SPN) 的定位很困难,通常需要电离辐射.
- 目前用于SPN检测的内镜导航方法面临限制.
- 肺部手术需要使用非电离成像技术.
研究的目的:
- 开发和评估一种新的,无辐射的光学方法,用于SPN定位.
- 为了利用近红外 (NIR) 透光可视化肺膜.
- 评估NIR透光用于胸内可视化的可行性.
主要方法:
- 在支气管树中插入了一个小型的NIR光源.
- 从胸腔侧检测到传输和散射的NIR光线,使用迷你胸腔镜和CMOS摄像头.
- 该技术利用肺组织的内在光学特性,避免使用对比剂.
主要成果:
- 通过直至4厘米的ex vivo猪肺膜体,清晰可视化组织结构.
- 在一个通风的猪中,从腔中持续检测出支气管NIR照明.
- 实现了分明的叶片结构和支气管粘膜的成像.
结论:
- 近红外 (NIR) 透光提供无辐射的胸内可视化.
- 这种技术显示出作为肺部手术中的活检指导辅助的前景.
- 为了临床验证和转化为人类应用,需要进一步的研究.
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