缺氧诱导的细胞外囊泡和癌症中的非编码RNA:在临床前动物模型中对瘤动态和治疗影响的系统审查
Joao Pedro R Afonso1, Simona Taverna2, Annalisa Pinsino2
1Graduate Program in Human Movement and Rehabilitation (PPGMHR), Evangelical University of Goiás (UniEVANGELICA), Anápolis 75083-515, GO, Brazil.
动物模型揭示了细胞缺氧如何影响癌症的发展,突出了微RNA和循环RNA作为关键调节剂. 操纵这些非编码RNA为各种癌症提供了潜在的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 癌症异质性受到基因表达的影响.
- 细胞外囊泡 (EVs) 和非编码RNA (ncRNAs) 对于理解瘤进展,诊断和治疗至关重要.
- 细胞缺氧是癌症发展的一个重要因素.
研究的目的:
- 使用动物模型系统地审查细胞缺氧对不同癌症类型的影响.
- 要突出微RNAs (miRNAs) 和循环RNAs (circRNAs) 在缺氧下瘤发育中的调节作用.
- 遵守系统性审查和元分析 (PRISMA) 报告的首选项目指南.
主要方法:
- 对PubMed/Medline和Scopus数据库的系统文献审查.
- 根据定义的标准,在对171篇文章进行初步搜索后,包括了25项研究.
- 分析的重点是研究癌症在低氧条件下的动物模型.
主要成果:
- 特定的circRNAs (例如circPFKFB4,circPDK1) 与乳腺癌和胰腺癌的不良预后和耐药性相关.
- 某些miRNAs (例如,miR-1287-5p,miR-133a) 作为受乳腺癌和结直肠癌中缺氧影响的瘤抑制剂.
- EVs可能促进瘤进展和转移;ncRNA操纵显示了治疗潜力.
结论:
- 动物模型对于在缺氧下阐明癌症的分子机制至关重要.
- 了解缺氧瘤中的ncRNA调节对于开发新型治疗策略至关重要.
- 向ncRNAs为癌症治疗提供了一个有前途的途径.
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