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Updated: Jan 10, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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与GBA1基因相关的转录基因特征揭示了帕金森病风险基因

Yanjun Liu1,2, Xi Luo1,2, Ronan M T Fleming1,2

  • 1School of Medicine, University of Galway, H91 TK33 Galway, Ireland.

Biomedicines
|November 27, 2025
PubMed
概括

GBA1基因中的致病变体增加了帕金森病 (PD) 的风险,但并非所有携带者都会患PD. 这项研究揭示了将GBA1变异与PD联系起来的共享的转录基因和代谢途径,确定了两种不同的疾病风险途径.

关键词:
在 GBA1 中,GBA1 是 GBA1 的代码.戈舍氏病是戈舍氏病的一种疾病.门德尔的随机化帕金森病是帕金森氏症的一种疾病.遗传风险 遗传风险 遗传风险神经退行症的神经退行症病变的发生和发病.

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