饮食糖单酸盐对生长性能,肠道屏障功能和断奶猪的肠道微生物群的影响 受到脂多糖的挑战
Huakai Wang1, Ruiyu Ma1, Renrong Qi1
1Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230001, China.
Animals : an open access journal from MDPI
|November 27, 2025
概括
糖单酸盐 (GML) 补充剂改善了受脂多糖化物 (LPS) 挑战的小猪的肠道健康. GML增强了肠道屏障功能,减少了炎症,积极调节了肠道微生物群的组成.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 断奶小猪的脂聚糖 (LPS) 挑战可以诱导肠道失调和炎症.
- 保持肠道屏障完整性和免疫平衡对于小猪健康和生长至关重要.
研究的目的:
- 为了研究甘单酸盐 (GML) 对LPS挑战的断奶小猪的生长性能,肠道形态,炎症反应和肠道微生物群的影响.
- 评估GML在减轻LPS引起的对小猪肠道健康负面影响方面的潜力.
主要方法:
- 18只断奶小猪被随机分配到三个组:对照组 (CON),LPS挑战组和LPS+GML (1000 mg/kg).
- 在21日,通过腹膜内注射给予LPS或盐水,注射后4小时采集样本.
- 分析了生长性能,肠道形态,血清炎症标志物,抗氧化酶活性和肠道微生物群组成.
主要成果:
- 补充GML并没有影响平均每日增益,料摄入量或增益与料比率.
- GML增加了小的高度,小的高度/密室深度比,以及紧密结合蛋白的表达 (claudin-1,ocludin).
- GML降低了血清二胺氧化酶和活性氧物种,降低了促炎性细胞因子mRNA表达 (IL-1β,IL-6,IL-8),并调节了肠道微生物群组成,增加了像Lactobacillus和Bifidobacterium这样的有益细菌,同时降低了Spirochaetota.
结论:
- 食GML补充剂有效地改善了肠道屏障功能,并减少了LPS挑战性猪仔的炎症.
- GML调节了肠道微生物群失生症,表明其作为料添加剂的潜力,可以提高断奶猪的肠道健康.
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