中具有抗菌性质的化合物 常见于温带树叶森林中
Aida Puia1, Stanca-Lucia Pandrea2,3, Jeanine Cruceru4
1Discipline of Family Medicine, Department Community Medicine, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 19 Moţilor Street, 400347 Cluj-Napoca, Romania.
Life (Basel, Switzerland)
|November 27, 2025
概括
来自罗马尼亚森林的食用具有强大的抗氧化和抗微生物特性,原因是酸等化合物. 这些天然提取物显示出作为常规抗生素的替代品的希望,特别是对抗耐药细菌.
科学领域:
- 菌类学 菌类学是指菌类学.
- 药理学是指药理学,即药理学是指药理学.
- 自然产品 化学 化学
背景情况:
- 是具有抗氧化和抗微生物特性的生物活性化合物的公认来源.
- 中的化合物特别以它们对抗耐药细菌的活性而闻名.
- 来自罗马尼亚落叶森林的可食用是天然生物活性剂的未充分探索的资源.
研究的目的:
- 评估四种可食用菌种的水提取物中的性状,抗氧化活性和抗微生物/抗菌特性.
- 确定负责观察到的生物活性的关键化合物.
- 评估这些提取物作为新型抗菌素配方来源的潜力.
主要方法:
- 准备了Cantharellus cibarius*,Russula virescens*,Lactarius piperatus*和Boletus edulis*的水提取物,这些水提取物可以在水中取.
- 高性能液体色谱学与质谱学 (HPLC-MS) 和里埃变换红外光谱学 (FTIR) 结合使用用于化学表征.
- 使用DPPH和ABTS试验评估了抗氧化活性.
- 使用扩散和杀时测试,对标准细菌菌株进行了抗微生物和抗菌活动的评估.
主要成果:
- 在HPLC-MS分析中,确定了包括酸,2,3-二基酸和甘酸在内的基酸作为主要的化合物.
- 特定的化合物与DPPH和ABTS的激素清除活动有积极的相关性.
- FTIR分析证实了提取物中脂质,蛋白质和多糖的存在.
- 所有的提取物都表现出对测试的病原体具有剂量依赖的抗微生物和抗菌活性.
结论:
- 研究的食用具有显著的抗氧化和抗微生物潜力,这归因于它们丰富的含量.
- 已确定的化合物,特别是基酸,是生物活性的主要贡献者.
- 这些提取物对开发替代抗菌剂来打击抗生素耐药性的发展具有前景.
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