在被怀疑患有局部过敏性鼻炎的受试者中,在自然过敏原暴露期间和经过鼻刺激测试后,鼻洗液中的粉尘特定IgE
Mohamad Mahdi Mortada1, Alaa Sherri2, Edyta Pietrowska3
1Department of Immunology and Allergy, International Doctoral School, Medical University of Łódź, 92-213 Łódź, Poland.
Life (Basel, Switzerland)
|November 27, 2025
概括
局部过敏性鼻炎 (LAR) 涉及鼻腔过敏症状,尽管皮肤测试呈阴性. 这项研究发现,家用粉尘虫过敏原的鼻洗中具有高的特定IgE,这表明在疑似LAR患者中存在局部过敏反应.
科学领域:
- 过敏学和免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 局部过敏性鼻炎 (LAR) 呈现出鼻炎症状,但皮肤刺伤测试 (SPT) 和血清特异性IgE (sIgE) 呈阴性.
- 对LAR的诊断依赖于使用特定过敏原的阳性鼻刺激试验 (NPT).
- 了解LAR的发病过程需要研究鼻腔粘膜中的局部过敏反应.
研究的目的:
- 在怀疑LAR的患者中评估临床症状和局部粘膜sIgE.
- 评估自然暴露和NPT与室内灰尘虫 (HDM) 过敏原对LAR症状和sIgE水平的影响.
- 探索局部sIgE生产在LAR诊断和发病过程中的作用.
主要方法:
- 包括25名涉嫌LAR的受试者.
- 使用总鼻腔症状评分 (TNSS) 和视觉模拟尺度 (VAS) 评估症状.
- 用HDM过敏原进行了NPT,并通过鼻水收集鼻分泌物以测量sIgE水平.
主要成果:
- 在HDM暴露增加的时期,TNSS和VAS显著增加.
- 在鼻水中增加了特定于Dermatophagoides pteronyssinus和Dermatophagoides farinae的sIgE水平.
- 在NPT后的8名受试者中证实了LAR,具有更高的VAS得分和挑战后增加的局部sIgE,尽管并不总是统计学上显著.
结论:
- 当地鼻腔sIgE评估对于了解LAR病原性是有价值的.
- 需要对更大的队列进行进一步的研究,以完善LAR诊断和治疗策略.
- 与sIgE一起研究局部炎症调解剂可能会增强对LAR的知识.
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