相关实验视频
Updated: Jan 10, 2026
07:42
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
18.6K
运动和物理治疗在化疗诱导的外周神经病变中的有效性:系统性审查
Javier Antonio Tamayo Fajardo1, Francisco León Parejo2
1Department of Health Sciences, Faculty of Nursing, Universidad de Huelva, 21007 Huelva, Spain.
Healthcare (Basel, Switzerland)
|November 27, 2025
概括
运动和物理治疗是安全有效的非药物治疗策略,用于管理化疗诱导的周围神经病变 (CIPN). 这些干预措施改善了症状和生活质量,为有限的药理疗法提供了可行的替代方案.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是癌症治疗的普遍和衰弱的副作用,影响高达65%的患者.
- CIPN显著降低了生活质量,增加了跌倒风险,并且经常需要调整剂量或停止化疗.
- 药理干预措施的有效性有限,这凸显了运动和物理治疗等非药理方法日益重要.
研究的目的:
- 系统地审查随机对照试验 (RCT),调查运动和物理治疗在预防或治疗CIPN中的有效性.
- 综合这些干预措施对各种神经病症症状和功能结果的影响的证据.
- 评估基于运动和物理治疗的CIPN管理策略的安全性和可行性.
主要方法:
- 按照PRISMA 2020指南进行了系统审查,搜索主要数据库,直到2025年5月.
- 包括2017年至2025年间发表的26项RCT,评估了各种运动方式和物理治疗技术.
- 方法质量使用PEDro尺度进行了评估,由于研究异质性,采用了叙事综合.
主要成果:
- 基于运动的干预措施 (有氧,抵抗,感觉运动,,多式) 和物理治疗模式 (手动治疗,光生物调节,Scrambler治疗,超声波,电刺激) 均显示了感觉/运动症状,平衡,力量和生活质量的改善.
- 干预的坚持率很高,从70%到95%,没有报告严重不良事件.
- 干预设计和结果测量的显著异质性排除了元分析,尽管有积极的发现.
结论:
- 运动和理疗是管理CIPN的安全,可行和有效的非药物选择.
- 鉴定出的异质性需要进一步进行高质量的RCT,以建立最佳的干预方案和标准化临床指导方针,用于CIPN管理.
- 这些发现支持将运动和物理治疗纳入常规癌症护理,以减轻CIPN的影响.
相关概念视频
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
01:27Peripheral Artery Disease III: Interprofessional Care
229
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
229
01:26Peripheral Artery Disease IV: Nursing Management
325
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
325