菌多糖类作为肝脏健康中的分子通路调节剂
Rafał Szelenberger1, Magdalena Więckowska1
1Biohazard Prevention Centre, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Molecules (Basel, Switzerland)
|November 27, 2025
概括
菌多糖体在保护肝脏免受酒精,脂肪肝和毒素造成的损伤方面显示出显著的前景. 这些天然化合物减少炎症和氧化应激,提供潜在的治疗途径.
科学领域:
- 菌类学 菌类学是指菌类学.
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 菌多糖是具有新兴肝保护性质的生物活性化合物.
- 肝病,包括与酒精有关的肝病 (ALD),与代谢功能障碍相关的脂肪肝病 (MAFLD) 和毒素诱导的肝损伤,构成了全球重大健康负担.
- 目前肝脏疾病的治疗策略存在局限性,需要探索新型药物.
研究的目的:
- 审查和综合目前关于真菌多糖的肝保护作用的科学证据.
- 探索这些化合物对各种肝脏损伤的保护作用的基础机制.
- 突出菌多糖的潜力,作为治疗肝脏疾病的治疗剂.
主要方法:
- 对调查真菌多糖和肝脏健康的临床前和临床研究的系统审查.
- 对来自各种真菌物种的多糖的化学结构和生物活动的数据进行分析.
- 检查详细介绍肝脏保护所涉及的分子通路和肠道微生物群调节的研究.
主要成果:
- 来自Lentinula edodes,Ganoderma lucidum和Cordyceps militaris等物种的真菌多糖体显示出显著的肝保护作用.
- 这些化合物有效地降低了氧化应激,炎症,并改善了肝病模型中的代谢平衡.
- 机制包括调节NF-κB,Nrf2,NLRP3炎症酶通路,以及有益调节肠道微生物群.
- 通过减少肝损伤生物标志物和改善组织病理损伤,证明了肝功能的改善.
结论:
- 菌多糖具有相当大的潜力,作为多功能肝脏保护剂,可以预防ALD,MAFLD和毒素诱导的肝损伤.
- 它们能够准参与肝损伤的多个途径,这强调了它们的治疗前景.
- 需要进一步的机制研究和临床验证,才能充分实现真菌多糖在肝病管理中的潜力.
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