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对HCV耐药多数和少数变种的图书统计分析
Omega Mathew Immanuel1, Olaoluwa Tolulope Fabiyi1, Kuat P Oshakbayev2
1Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana 010000, Kazakhstan.
International journal of environmental research and public health
|November 27, 2025
概括
关于型肝炎病毒 (HCV) 耐药性的研究表明,人们正在转向直接作用抗病毒药物 (DAA). 然而,全球研究集中在高收入国家,需要更广泛的数据纳入有效的消除策略.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 图书统计学 图书统计学
- 药物耐药性 药物耐药性 药物耐药性
背景情况:
- 肝炎C病毒 (HCV) 耐药变体的研究已经增长,但全球贡献和趋势需要进一步了解.
- 本文提供了一个文献分析,用于绘制1999-2025年HCV耐药性研究主题和趋势的地图.
研究的目的:
- 分析关于型肝炎病毒 (HCV) 耐药变异的文献数据.
- 确定HCV耐药性研究的研究主题,趋势和全球贡献.
主要方法:
- 在Web of Science和Scopus数据库中搜索关于HCV耐药变种 (1999-2025) 的出版物.
- 使用Bibliometrix和VOSviewer提取和分析出版物元数据和内容.
- 利用关键词的同时出现和集群分析来识别研究模式.
主要成果:
- 2014年后,出版物激增,主要是直接作用抗病毒药物 (DAA),重点关注DAA的疗效,耐药性机制和基因定型.
- 美国在出版物和引用方面领先;圣保罗大学是最具生产力的机构.
- 协作网络集中在高收入国家;像Y93H这样的低频电阻相关替代物 (RAS) 在少数变体中被发现.
结论:
- 该领域已成功过渡到DAA时代,但研究成果和合作主要由高收入国家主导.
- 低收入和中等收入国家 (LMICs) 的数据存在重大差距.
- 整合LMIC数据对于制定有效的全球HCV消除策略至关重要.
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