尼古丁胺和Pyruvate作为潜在的治疗干预对代谢功能障碍在初级开放角度玻璃眼-A叙述审查中
Nathan Schanzer1, Alon Harris1, Kunal Kanwar2
1Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Journal of clinical medicine
|November 27, 2025
概括
尼古丁胺和酸可以通过解决代谢功能障碍,为初级开角玻璃眼 (POAG) 提供神经保护. 然而,人类数据有限,需要进一步的长期研究以临床使用.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 代谢医学是一种代谢医学.
背景情况:
- 线粒体功能障碍和氧化应激与初级开角青光眼 (POAG) 病变发生有关.
- 尼古丁胺和酸盐与年龄相关的下降可能会增加POAG的脆弱性.
- 目前的POAG治疗方法没有解决与非眼内压 (IOP) 相关的疾病驱动因素,如氧化应激.
研究的目的:
- 在POAG中审查和批判性地评估关于尼古丁胺和酸盐补充剂对代谢功能障碍的研究.
- 评估这些补充剂在缓解POAG进展方面的潜力.
- 确定当前研究中的差距,并建议未来的方向.
主要方法:
- 在PubMed,ClinicalTrials.gov和谷歌学者的综合文献搜索 (1979年10月 - 2025年11月).
- 在POAG.中包括调查尼古丁胺和酸盐的干预研究.
- 相关文章的参考交叉匹配.
主要成果:
- 试点研究表明,尼古丁胺和酸可以提供一些视网膜神经保护和短期视觉功能改善.
- 现有的研究主要基于动物模型.
- 人类研究数据的范围和持续时间有限.
结论:
- 尼古丁胺和酸盐通过准代谢功能障碍和氧化应激,显示出POAG管理的前景.
- 需要更广泛的,长期的人体试验,使用更大,更多样化的人口.
- 需要进一步的研究来确定POAG治疗的安全性和临床效用.
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