在长期的韩国队列中,使用TNF抑制剂治疗结性脊髓炎患者的癌症的年龄特定风险因素
Yeo-Jin Lee1,2, Minji Kim1, Soo Min Ahn1
1Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Journal of clinical medicine
|November 27, 2025
概括
年龄是TNF抑制剂治疗结性脊髓炎患者的主要癌症风险因素. 癌症风险随着年龄的增长而增加,不同的因素影响了年轻人与老年患者的风险.
科学领域:
- 类风湿病学 类风湿病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 瘤坏死因子 (TNF) 抑制剂是结性脊髓炎 (AS) 的标准.
- 关于接受TNF抑制剂治疗的年轻AS患者癌症风险的数据有限.
- 亚洲人群具有独特的风险概况,需要进行调查.
研究的目的:
- 在AS患者的TNF抑制剂治疗期间确定癌症风险因素.
- 在韩国AS队列中评估特定年龄的癌症风险.
- 确定不同年龄组与癌症相关的因素.
主要方法:
- 以TNF抑制剂治疗的810名AS患者的回顾性分析 (2003-2023年).
- 考克斯回归和费尔斯的惩罚可能性用于预测分析.
- 卡普兰-梅尔曲线为特定年龄的累积癌症发病率.
主要成果:
- 总体癌症发病率:每10万人/年中有323人.
- 年龄是主要的独立风险因素 (每年危险增加5.7%).
- 风险因素因年龄而异:女性性别/ESR (<40岁) 与年龄 (≥40岁).
结论:
- 在服用TNF抑制剂的AS患者中,年龄是癌症的主要独立风险因素.
- 癌症风险决定因素在各个年龄层之间存在显著差异.
- 年龄特定的癌症风险评估对于AS管理至关重要.
更多相关视频
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
616
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
704
相关概念视频
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Cancer Survival Analysis
624
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
624
Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Factors Affecting Protein-Drug Binding: Patient-Related Factors
275
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
275
Longitudinal Research
13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K
