在体外受精过程中产生的双胞胎妊娠与自发双胞胎妊娠有什么区别? 一个回顾性队列研究
Ahmet Zeki Nessar1, Şebnem Karagün2, Fikriye Işıl Adıgüzel3
1Division of Perinatology, Department of Obstetrics and Gynecology, Osmaniye State Hospital, Osmaniye 80000, Turkey.
Journal of clinical medicine
|November 27, 2025
概括
在体外受精 (IVF) 怀孕的双胞胎怀孕显示出与自发妊娠相比,早产和胎儿生长限制的风险增加. 然而,新生儿结局在两组之间仍然相似.
科学领域:
- 生殖医学 生殖医学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 周围生理学 周围生理学
背景情况:
- 双胞胎怀孕 (DC/DA) 可以由体外受精 (IVF) 或自发受孕引起.
- 将这些组之间的结果进行比较对于了解试管婴儿对双胞胎怀孕的影响至关重要.
研究的目的:
- 为了比较通过试管婴儿怀孕的DC/DA双胞胎怀孕与自发怀孕之间的周产期结果.
- 确定与DC/DA双胞胎体外受精相关的特定风险和并发症.
主要方法:
- 一项比较性研究涉及99名女性与IVF怀孕的DC/DA双胞胎和92名女性与自发DC/DA双胞胎.
- 收集的数据包括母亲的人口统计数据,先前存在的疾病,产科病史,妊娠并发症 (例如,早产,FGR) 和新生儿结果 (例如,Apgar分数,NICU入院).
主要成果:
- 试管婴儿怀孕与更老的母亲年龄和更高的初级生育率有关.
- 在试管婴儿组中观察到显著更高的早产率 (59.8%与30.4%) 和胎儿生长限制 (FGR).
- 在试管婴儿组,紧急剖腹产的发生率更高 (81.8%对比55.8%).
- 没有发现胎盘前,橄水,TTTS,胎儿水或新生儿整体结局的显著差异.
结论:
- 通过试管婴儿构思的DC/DA双胞胎怀孕面临着早产和FGR的高风险.
- 尽管有这些并发症,新生儿的结局与自发受孕的DC/DA双胞胎相似.
- 这凸显了IVF怀孕DC/DA双胞胎怀孕期间需要密切监测的必要性.
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