上部胃肠道克罗恩病:揭示了模糊的L4分类含义
Francesca Lusetti1, Cristina Bezzio2,3, Alice De Bernardi1
1IBD Unit, Gastroenterology Unit, Rho Hospital, ASST Rhodense, 20017 Rho, MI, Italy.
上部胃肠道克罗恩病 (UGI-CD) 缺乏标准定义,影响了诊断和护理. 研究重点包括基于细分的报告和治疗到目标的策略,以获得更好的患者结果.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病是什么
- 临床研究 临床研究
背景情况:
- 上部胃肠道克罗恩病 (UGI-CD) 的定义不一致,并且未得到充分的认可.
- 缺乏统一的定义阻碍了流行病学研究,诊断和量身定制的患者护理.
- 缺少特定细分市场的标准阻碍了研究的可复制性和可比性.
研究的目的:
- 综合当前关于UGI-CD定义,流行,诊断和管理的知识.
- 确定差距,并为UGI-CD提出一个务实的方法.
- 突出提高UGI-CD认可和成果的研究重点.
主要方法:
- 成人和儿科研究的叙述综合和主要指导方针.
- 检查定义,流行,诊断和管理策略.
- 将结果映射到特定的上部肠道段 (食道,胃,十二指肠,近壁小肠).
主要成果:
- UGI-CD的定义是异质的,流行率是可变的.
- 诊断包括食管胃管腺镜检查,活检,截面成像和肠镜检查.
- 抗TNF药物对食道胃腺疾病是有效的;管理需要针对细分市场的监测.
结论:
- 在定义,流行病学和管理方面,UGI-CD仍然标准化不佳.
- 提出了一个务实的诊断和监测途径.
- 研究重点包括基于细分的报告,上部GI-only队列和治疗目标验证.
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