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口腔状细胞癌中假定癌症干细胞标记物的表达:与临床病理学特征的相关性

Anđelija Petrović¹, Slavko Mojsilović², Diana Bugarski²

¹Group for Nutritional Biochemistry and Dietology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.

International journal of molecular sciences

|November 27, 2025

概括

癌症干细胞标记物CD44,CD133和CD166在口腔状细胞癌 (OSCC) 预后方面显示出潜在的潜力. CD133的表达与侵袭深度相关,而CD166和CD44/CD166的共同表达与减少的唾液流有关.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
生物标志物生物标志物

背景情况:

口腔状细胞癌 (OSCC) 是一种具有不良预后标记的侵袭性癌症.
确定可靠的预后指标对于OSCC患者管理至关重要.

研究的目的:

在OSCC中评估癌症干细胞标记物CD44,CD133和CD166的表达.
研究这些标记物与瘤入侵和唾液功能等临床参数的关联.

主要方法:

分析了来自12名患者的OSCC组织样本.
流细胞计量量化CD44,CD133和CD166的表达.
与临床数据的相关性分析,包括侵入深度和唾液流量.

主要成果:

CD44的高表达 (中位数为96.4%) 和CD166 (中位数为85.5%),CD133的低表达 (中位数为1.5%).
CD133表达与入侵深度正相关 (p ≤0.05).
CD166和CD44+/CD166+的表达与唾液流速负相关 (p ≤0.01).

结论:

假定癌症干细胞标志物,特别是CD133,可以作为OSCC的预后指标.
需要进一步的研究来验证它们在OSCC管理中的临床实用性.

关键词:

临床病理学特征临床病理学特征口腔状细胞癌的癌症.假定的癌症干细胞标记物瘤的入侵深度是什么

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