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联合口服避孕药和血栓形成的风险

Jamilya Khizroeva¹, Victoria Bitsadze¹, Gennady Sukhikh²

¹Department of Obstetrics, Gynecology and Perinatal Medicine, The I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., 119991 Moscow, Russia.

International journal of molecular sciences

|November 27, 2025

概括

联合口服避孕药 (COCs) 通过影响凝血因子和内皮功能,增加静脉血栓形成的风险. 了解这些机制对于安全的COC处方和患者监测至关重要.

科学领域:

药理学药理学是指药理学的学科.
血栓形成研究研究
妇女健康妇女健康

背景情况:

组合口服避孕药 (COC) 是广泛使用的可逆避孕药.
尽管有好处,但COC与静脉血栓形成的风险增加有关.
了解COCs的原血栓机制对于患者的安全至关重要.

研究的目的:

审查与口服避孕药使用相关的血栓形成的关键病原遗传机制.
阐明促进凝块形成的COCs诱导的分子和生理变化.

主要方法:

对联合口服避孕药和血栓形成的研究的文献综述.
分析病原遗传途径,包括凝血,抗凝血,纤维溶解和内皮功能.
检查与血栓形成风险相关的生物化学和血液学标志物.

主要成果:

COCs改变凝血因子水平,降低抗凝血蛋白 (抗血,蛋白S),并诱导对激活的蛋白C的抗性.
机制包括降低组织因子通路抑制剂 (TFPI),内皮激活和抑制纤维素分解.
荷尔蒙的影响导致同类氨酸失衡,氧化 (NO) 缺乏,血压升高,胰岛素抵抗,以及炎症标志物 (CRP,PAI-1) 的升高.
增加血小板粘附性和聚合性进一步导致血栓形成风险.

结论:

的使用与影响凝血,纤维溶解和内皮功能的多因素原血栓效应有关.
临床医生必须评估个体患者的风险因素,并定期监测患者以减轻并发症.
需要进一步研究个性化风险评估和更安全的避孕替代方案.

关键词:

组合口服避孕药是一种口服避孕药.对于COCs的组成.血栓形成的危险因素血栓形成的原因是血栓形成.COCs 的血栓性影响.

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