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法尔内索伊德X受体激动剂INT-787 抑制肝脏线粒体功能障碍在一个饮食诱导的MASH的ob/ob小鼠模型中

Laura Giuseppina Di Pasqua1, Giuseppina Palladini1,2, Anna Cleta Croce3,4

  • 1Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.

International journal of molecular sciences
|November 27, 2025
PubMed
概括

法尔内索伊德-X受体 (FXR) 激素INT-787可以防止在代谢功能障碍相关的脂肪肝炎 (MASH) 中的线粒体损伤. INT-787通过上调MIC19来恢复线粒体功能,这对内部线粒体膜完整性至关重要.

关键词:
在 FXR 和 FXR 之间.在INT-78787中使用.马什 (MASH) 是一个非常重要的产品.在MIC19中,MIC19是MIC19中的一个.线粒体中的线粒体.

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