纤维细胞激活蛋白α (FAP) 表达与疾病复发和对先进的清细胞脏细胞癌中铁氨酸激酶抑制剂的反应不佳有关
María Riaza Montes1,2, Beatriz Suárez3, Jon Danel Solano-Iturri2,4
1Department of Urology, Galdakao-Usansolo University Hospital, 48960 Usansolo, Spain.
International journal of molecular sciences
|November 27, 2025
概括
在晚期清细胞细胞癌 (ccRCC) 中,流体纤维细胞激活蛋白-α (FAP) 表达与较差的存活率和对氨酸激酶抑制剂 (TKI) 的耐药性相关. FAP免疫组织化学 (IHC) 可以作为ccRCC患者的预后和预测生物标志物.
科学领域:
- 在瘤学瘤学.
- 癌症生物标志物 癌症生物标志物
- 细胞癌研究 细胞癌研究
背景情况:
- 晚期清晰细胞细胞癌 (ccRCC) 缺乏可靠的预后和预测生物标志物.
- 纤维细胞激活蛋白-α (FAP),癌症相关纤维细胞 (CAFs) 的标记物,显示出预测瘤攻击性和治疗耐药性的潜力.
研究的目的:
- 在晚期ccRCC中研究 stromal FAP表达的临床意义.
- 为了将FAP表达与临床病理特征,生存结果和对氨酸激酶抑制剂 (TKI) 治疗的反应相关联.
主要方法:
- 对137名晚期cccRCC患者进行了回顾性分析,并进行长期随访.
- 在初级瘤样本上进行FAP免疫组织化学 (IHC).
- FAP表达与组织学等级,瘤阶段,无病生存率 (DFS),总生存率 (OS) 和放射性反应 (RECIST标准) 与一线TKIs的相关性.
主要成果:
- 在高等级的瘤中观察到更高的FAP阳性CAF百分比,先进的局部入侵 (pT3-4),以及先进的临床阶段 (NCCN阶段III-IV).
- 流体FAP表达与较短的DFS和OS显著相关.
- 缺乏FAP表达的瘤对TKI治疗的完整反应的可能性更高.
结论:
- 流体FAP表达是晚期ccRCC中显著的负预后因素.
- 在ccRCC中,FAP IHC可以作为TKI治疗反应的有价值的预测生物标志物.
- 对于先进的ccRCC管理,需要对FAP IHC进行进一步的临床验证.
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