作为碳源的 Agave 果实素,为预防和治疗 Helicobacter pylori 感染制定基于后生物的策略
Enrique A Sanhueza-Carrera1,2, Natalia C Hernández-Delgado1,3, Carolina Romo-González4
1Laboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Ciudad de México 04530, Mexico.
乳酸细菌后生物体,增强了阿加韦果实素,显示强大的抗微生物和抗菌膜活动对Helicobacter pylori. 这提供了一个有前途的非抗生素策略来对抗H. pylori感染.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 生物技术是生物技术.
背景情况:
- 杆菌感染了全球50%以上的人口,导致胃炎和胃癌.
- *常规抗生素治疗*H. pylori*可能导致失生症和抗菌素耐药性.
- * 后微生物,即益生菌的代谢产物,正在成为有效的抗微生物替代品.
研究的目的:
- * 研究乳酸细菌 (LAB) 后生物的抗菌和抗菌膜潜力.
- * 为了评估来自甲的格拉米南类果实素 (GTF) 对LAB代谢最终产品的影响.
- * 评估用GTFs生产的LAB后生物对*H. pylori*的疗效.
主要方法:
- *INP_MX_001 LAB菌株的培养,其中含有三种不同的格拉米南类果 (GTF).
- *对LAB排泄/分泌 (E/S) 产品和外聚糖 (EPSs) 进行活动测试.
- * 在实验室测试LAB后生物药物以抑制*H. pylori*的生存和生物膜形成.
主要成果:
- *LAB后生物制剂,特别是当与GTFs一起生产时,显示出明显抑制H. pylori*存活率.
- * 经过测试的后生菌在体外有效降低了H. pylori生物膜的形成.
- * 甲衍生GTFs影响了LAB代谢最终产品的组成和有效性.
结论:
- * LAB 衍生后生物,尤其是用 GTF 培养的后生物,代表了对抗 H. pylori 的新方法.
- * 这一策略提供了一个有希望的非抗生素替代方案来管理H. pylori*殖民.
- *对GTF调节的LAB后生物的进一步研究可能会导致新的治疗干预措施.
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