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Updated: Jan 10, 2026

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兰氏菌 (Lactobacillus rhamnosus) GG和兰氏菌 (Lactobacillus paracasei) IMPC2.1缓解LPS诱导的上皮屏障功能障碍:专注于自调节

Antonella Orlando¹, Fatima Maqoud¹, Domenica Mallardi¹

¹Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS "S. de Bellis", 70013 Castellana Grotte, Italy.

International journal of molecular sciences

|November 27, 2025

概括

乳杆菌益生菌LGG和L. paracasei通过改善紧密的结节和自来保护肠道屏障. 它们抵消炎症和亡,突出了它们对肠道健康的治疗潜力.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
细胞生物学细胞生物学

背景情况:

肠上皮屏障对于肠道平衡至关重要.
它的完整性受到炎症和微生物失衡 (失生症) 的威胁.

研究的目的:

为了研究乳杆菌rhamnosus GG (LGG) 和乳杆菌paracasei IMPC2.1对表皮屏障功能的影响.
探索它们在调节自,炎症和亡对脂聚糖 (LPS) 的反应中的作用.

主要方法:

暴露于LPS的Caco-2细胞模型.
评估横体电阻 (TEER) 和细胞透性.
西方斑点和免疫光对于紧密结合蛋白,自标记物 (LC3-II,p62),mTOR,环氧化酶-2 (Cox-2) 和Bax.

主要成果:

LPS 损害了屏障功能,减少了紧结蛋白 (ZO-1,Occludin) 和破坏了自流.
LGG和L. paracasei部分逆转了LPS诱导的屏障功能障碍.
益生菌恢复了紧结的表达,缓解了自功能障碍,并抑制了炎症 (Cox-2) 和亡 (Bax) 标志物.

结论:

LGG和L. paracasei通过调节紧密的结节,炎症和亡来增强表皮屏障功能.
这些益生菌通过调节自来抵消LPS诱导的肠道屏障功能障碍.
LGG和L. paracasei在治疗肠道屏障完整性问题方面具有显著的治疗潜力.

关键词:

牛乳杆菌帕拉凯西 (Lactobacillus paracasei) 是一个乳杆菌拉姆诺索斯 GG 自自是自的过程.这是一种炎症炎症炎症炎症.肠道的通透性肠道的通透性脂多糖 (LPS) 是一种脂多糖.益生菌是一种益生菌.

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