益生菌在衰老中的调节:在Caenorhabditis elegans中具有特定菌株的老年保护作用
Barbara Sciandrone1, Diletta Francesca Squarzanti2, Patrizia Malfa2
1Department of Biotechnology and Biosciences BtBs, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy.
International journal of molecular sciences
|November 27, 2025
概括
益生菌显示出健康衰老的前景. 特定菌株通过影响关键的长寿基因改善了虫的运动,减少了氧化应激,增强了学习,并延长了寿命.
科学领域:
- 微生物学 微生物学
- 老年学是一门学科.
- 分子生物学分子生物学
背景情况:
- 老年人群面临着由于脆弱性而增加的疾病脆弱性.
- 益生菌正在成为老年保护剂,可能通过支持肠道健康和调节衰老过程,如炎症,认知和新陈代谢.
研究的目的:
- 为了研究四种特定的益生菌菌株的老年保护潜力:Lacticaseibacillus paracasei LPC1114,Limosilactobacillus reuteri PBS072,Bifidobacterium breve BB077和Bifidobacterium animalis亚种. 牛奶糖 BL050.0. 牛奶糖 的
- 在Caenorhabditis elegans老化模型中评估这些益生菌对中年人群健康参数的影响.
主要方法:
- 利用Caenorhabditis elegans作为一个模型生物来研究衰老.
- 评估健康周期参数,包括寿命,运动性,反应性氧物种 (ROS) 水平,脂素积累和认知功能 (关联性学习和化学反应).
主要成果:
- 益生菌的影响是菌株特异性的.
- L. reuteri PBS072和B. lactis BL050显著改善了运动能力,并降低了ROS水平.
- B. breve BB077,L. paracasei LPC1114和L. reuteri PBS072增强了关联学习,而B. lactis BL050则改善了化学反应.
- L. paracasei LPC1114和L. reuteri PBS072延长了长寿基因skn1,sir2.1和daf16.1的介导下最大寿命.
结论:
- 益生菌具有多方面的,菌株特定的老年保护性质.
- 这些发现支持益生菌作为促进健康衰老的基于微生物群的干预措施的潜力.
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