相关实验视频

Updated: Jan 10, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

在三阴性乳腺癌中剖析非免疫瘤微环境:分子亚型特定模式和预后影响

Antonia Syrnioti¹, Eleni Timotheadou², Vasileios Papadopoulos³

¹Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

International journal of molecular sciences

|November 27, 2025

概括

三重阴性乳腺癌 (TNBC) 呈现出多种不同的分子亚型. 它们的非免疫瘤微环境 (包括纤维细胞和细胞外基质) 的差异可能会影响预后并指导个性化治疗.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
瘤微环境研究研究

背景情况:

三阴性乳腺癌 (TNBC) 是一种异质性疾病,具有不同的分子亚型 (BL1,BL2,IM,M,MSL,LAR).
虽然TNBC亚型的免疫方面是已知的,但非免疫性 stromal 组件是未被认可的.
了解非免疫微环境对于TNBC生物学至关重要.

研究的目的:

对跨TNBC分子亚型的非免疫微环境差异的证据进行审查和综合.
专注于与癌症相关的纤维细胞 (CAF),血管性,细胞外基质 (ECM),表皮细胞-介质细胞转换 (EMT) 和代谢重编程.
突出特定亚型的特征及其潜在的临床意义.

主要方法:

现有科学文献的叙述性审查.
整合了多项关于TNBC分子亚型的研究数据.
专注于瘤微环境的非免疫层和结构组件.

主要成果:

在TNBC分子亚型的非免疫微环境中存在显著差异.
检查的关键组件包括CAF,血管特征,ECM动态,EMT和代谢-低毒性重编程.
鉴定了基层结构和代谢适应的亚型特定特征.

结论:

非免疫性微环境在TNBC分子亚型之间存在显著差异.
这些变化可能具有预后和预测价值.
向瘤-肌瘤接口为TNBC提供了个性化治疗策略的潜力.

关键词:

血管新生是因为血管新生.与癌症相关的纤维细胞.表皮介质介质的过渡.细胞外矩阵是细胞外矩阵.基因表达的基因表达方式组织学组织学缺氧缺氧是指缺氧的情况.免疫组织化学免疫组织化学代谢重编程是指代谢重编程.这是一个渐进的过程.

更多相关视频

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...