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高灵敏心脏热素和缺血修饰性白蛋白在患有下肢外周动脉疾病的患者中的作用

Vinko Boc^1,2, Aleš Blinc^1,2, Anja Boc^1,3

¹Department of Vascular Diseases, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.

International journal of molecular sciences

|November 27, 2025

概括

高灵敏性心脏特罗素 (hs-cTn) 和缺血修饰性白蛋白 (IMA) 在评估外围动脉疾病 (PAD) 风险方面表现有前途. 这些生物标志物可能会改善患者分层,超出临床表现,以便更好地管理.

科学领域:

心血管和血管医学中的生物标志物.
临床风险分层战略.临床风险分层策略.
在血管疾病中氧化应激的分子机制.

背景情况:

周围动脉疾病 (PAD) 是一个重大的全球健康挑战.
目前PAD的预后工具缺乏准确性,导致患者的结果各不相同.
需要可靠的生物标志物来提高PAD风险评估和个性化治疗.

研究的目的:

评估高灵敏性心脏热素 (hs-cTn) 和缺血修饰性白蛋白 (IMA) 作为PAD预后生物标志物的潜力.
探索hs-cTn和IMA水平与PAD严重程度和临床结果的相关性.
评估这些生物标志物的增量预后价值,与传统的临床评估相比.

主要方法:

观察性研究将hs-cTn和IMA水平与PAD严重程度和临床事件相关联.
分析与患者症状和疾病进展相关的生物标志物水平.
关于在PAD群体中hs-cTn和IMA的现有研究的文献综述.

主要成果:

Hs-cTn水平与PAD严重程度相关,并预测肢体和心血管不良事件,表明亚临床心肌损伤.
IMA水平也与PAD严重程度相关,随着疾病的进展而增加,并反映氧化应激.
生物标志物水平可能提供超出临床表现的预后信息,特别是在晚期PAD.

结论:

在PAD患者中,hs-cTn和IMA显示出作为精细化风险分层的有价值工具的潜力.
生物标志物值的标准化和前性验证对于临床整合至关重要.
需要进一步的研究来证实hs-cTn和IMA在管理PAD中的实用性.

关键词:

生物标志物生物标志物高灵敏度的托罗邦尼.缺血修饰的专辑蛋白.周围动脉疾病周围动脉疾病风险分层的分层化

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