在腹腔大动脉中检测口腔细菌 动脉硬性斑块-它们能走多远?
Aleksandar Šubarić1, Zoran Arsić1, Đorđe Mihailović1
1Department of Dentistry, Faculty of Medicine, University of Priština in Kosovska Mitrovica, 38220 Kosovska Mitrovica, Serbia.
Medicina (Kaunas, Lithuania)
|November 27, 2025
概括
在腹腔大动脉动脉瘤 (AAA) 患者的动脉斑中发现了像 Porphyromonas gingivalis 这样的牙周病原体,这表明口腔健康和心血管疾病进展之间存在联系.
科学领域:
- 牙周病学 牙周病学
- 心血管医学 心血管医学
- 微生物学 微生物学
背景情况:
- 动脉样性心血管疾病 (ASCVD) 是全球主要的死亡原因.
- 慢性感染和炎症,包括由牙周病原体引起的慢性感染和炎症,有助于血管病理.
- 牙周病与全身炎症和心血管事件有关.
研究的目的:
- 检测腹腔大动脉动脉瘤 (AAA) 患者的动脉硬性斑块中的口腔病原体的细菌DNA.
- 探索口腔健康指数与这些细菌在动脉斑块中的存在之间的相关性.
- 调查口腔细菌在AAA发展中的潜在作用.
主要方法:
- 分析了40名患有牙周炎和AAA的患者.
- 下生物膜和动脉斑样本使用PCR测试特定的牙周病原体.
- 评估了牙科指数 (PI,GI,SBI,PPD),并进行了统计分析.
主要成果:
- Porphyromonas gingivalis在口腔和动脉斑块之间显示出最高的一致性.
- 丹内拉·福西提亚和聚合菌 (Aggregatibacter actinomycetemcomitans) 也显示出一致性.
- 在A. actinomycetemcomitans,P. gingivalis和牙科指数之间发现了显著的正相关性.
结论:
- 牙周病原体在口腔和动脉斑块中的存在支持它们在动脉样硬化和动脉瘤变化中的作用.
- 牙周健康与预防心血管风险有关.
- 需要进一步的纵向研究来确定因果机制.
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