ADAS-Cog轨迹与在3年内重复的非侵入性干预后,痴呆症预期的下降不同
Maria Anabel Uehara1, Sumeet Kalia2, Mari Garcia Campuzano3
1Biomedical Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.
Medicina (Kaunas, Lithuania)
|November 27, 2025
概括
重复的非侵入性治疗,如认知训练和大脑刺激,在1-3年内显著减缓了阿尔茨海默病患者的认知衰退. 治疗之间的更长时间休息加剧了衰退,这表明持续的干预是痴呆症管理的关键.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 临床神经学 临床神经学
背景情况:
- 非药物干预,包括认知训练,跨电刺激 (tES) 和重复性跨磁刺激 (rTMS),显示出改善阿尔茨海默病 (AD) 和痴呆症认知功能的潜力.
- 重复的非侵入性干预对痴呆患者的认知轨迹的长期疗效和影响在很大程度上是未知的.
- 这项研究解决了了解这些干预措施在长时间内持续的影响的需要.
研究的目的:
- 调查一到三年内进行的重复的非侵入性干预是否与相比典型的阿尔茨海默病进展相比,与较慢的认知衰退有关.
- 为了确定没有治疗的较长时间间隔是否预测干预期后更大的认知衰退.
- 评估非药物干预措施在管理痴呆症认知衰退中的长期有效性.
主要方法:
- 患有痴呆症或AD的73名参与者接受了2到9个非侵入性治疗 (tES,rTMS,认知训练) 块.
- 使用阿尔茨海默氏病评估尺度-认知子尺度 (ADAS-Cog) 评分长度追踪认知下降,长达36个月.
- 使用混合效应模型将观察到的认知衰退率与已确定的AD进展率进行比较,并根据基线因素进行调整.
主要成果:
- 参与者表现出认知衰退的速度明显低于参考AD进展率 (p < 0.001).
- 许多参与者在持续1至3年的治疗期间保持稳定的ADAS-Cog得分.
- 较长的无治疗间隔与治疗后认知衰退的增加显著相关 (p < 0.001),而AD药物没有显著影响.
结论:
- 重复的非侵入性干预,当在长时间内一致应用时,似乎可以减轻痴呆症患者的认知衰退.
- 这些发现支持个性化,长期非侵入性治疗策略的可行性和有效性,用于管理痴呆症.
- 持续的干预提供至关重要,因为长时间的休息与加速的认知衰退相关.
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