椎间盘退化和端板变化对塞法林透到椎间盘的影响
Aleksejs Repnikovs1,2, Kalvis Briuks2, Artūrs Paulausks3,4
1Department of Orthopaedics, Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia.
Medicina (Kaunas, Lithuania)
|November 27, 2025
概括
脊椎间盘中的预防性塞法林水平有所不同. 在Modic II型变化的磁盘中发现了较高的塞法佐林度,这表明端板变化可能会影响脊柱手术期间的抗生素透.
科学领域:
- 脊柱外科手术 脊柱外科手术
- 预防传染病 预防传染病
- 药理动力学 药理动力学
背景情况:
- 术前的塞法林是脊椎间盘外科手术的标准,以预防脊髓瘤炎.
- 了解抗生素透到磁盘对于优化预防至关重要.
研究的目的:
- 评估磁盘退化和端板变化对塞法林透到椎间盘的影响.
- 为了将塞法佐林度与基于成像的磁盘和端板病理学分级相关联.
主要方法:
- 经过微隔膜切除术的成年患者接受了2g的塞法林预防.
- 椎间盘和血液样本通过HPLC分析了塞法林.
- 磁盘退化 (Pfirrmann) 和端板变化 (Modic) 使用MRI进行分级.
主要成果:
- 在Modic II型变化 (14.6μg/g) 与0/I型 (9.2-10.2μg/g) 相比,Cefazolin度在Modic II型变化 (14.6μg/g) 的磁盘中显著更高.
- 与Modic 0/I (10-25%) 相比,Modic II变化的患者中,更高的百分比达到>16μg/g (35.4%) 的度.
- 没有发现患者年龄,体重或时间与腹腔内塞法索林水平之间的显著相关性.
结论:
- 94%的磁盘样本超过了黄金葡萄球菌的最低抑制度 (>4μg/g).
- 在椎间盘内观察到塞法佐林度的显著变化.
- 莫迪克II型末盘变化与磁盘中较高的塞法佐林度有关.
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