运动调节Myostatin-FOXO通路在癌症白内障的小鼠模型中的运动调节:系统性审查
Zahra Zare1, Mahfoodha Al Kitani2, Shahnaz Shahrbanian1
1Department of Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran P.O. Box 14115-111, Iran.
Medicina (Kaunas, Lithuania)
|November 27, 2025
概括
运动有助于通过调节肌素-FOXO通路来对抗结肠直肠癌缓解症的肌肉损失. 不同的运动类型会影响特定的肌肉消耗蛋白质,这表明定制方法可能是有益的.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 癌症缓解症是一种代谢综合征,导致结肠直肠癌 (CRC) 的肌肉消耗.
- 涉及MuRF-1和Atrogin-1的myostatin-FOXO途径驱动了这种肌肉损失.
- 运动是一种潜在的干预措施,但它对CRC缓解症的这种途径的影响尚不清楚.
研究的目的:
- 审查临床前证据,关于运动对肌静止素-FOXO通路在CRC缓冲症的影响.
- 综合关于不同运动方式如何影响肌肉代谢的关键分子调节者的研究结果.
主要方法:
- 在主要的科学数据库中进行全面的文献搜索.
- 包括在内的小鼠CRC模型 (C26或ApcMin/+) 接受有氧,阻力或组合运动.
- 评估作为主要结局的肌素,FOXO,MuRF-1和Atrogin-1表达.
主要成果:
- 11项研究符合纳入标准,具有良好的方法质量.
- 有氧运动始终降低了MuRF-1和炎症;抵抗/异常训练更有效地抑制了FOXO和Atrogin-1.
- 耐力/异常训练增强了合成代谢信号传递 (mTORC1),而有氧训练提高了氧化能力.
结论:
- 运动干预可以通过myostatin-FOXO途径减轻CRC缓解症的骨肌肉代谢.
- 运动方案的多样性和有限的直接肌肉静止素数据强调了标准化和翻译研究的必要性.
- 本综述提供了第一个关于运动在调节CRC缓解症中这一途径中的作用的专注综合.
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