在接受免疫检查点抑制剂治疗的患者中,性功能障碍的患病率和特征
Betul Aktepe1, Oktay Halit Aktepe2, Pinar Ezgi Dama2
1Department of Psychiatry, Urla State Hospital, Ministry of Health, Izmir 35430, Turkey.
Medicina (Kaunas, Lithuania)
|November 27, 2025
概括
性功能障碍 (SD) 影响了近三分之二的癌症患者免疫检查点抑制剂 (ICI). 女性性别,年龄较大和晚期癌症预测这种常见的副作用,需要定期进行性健康评估.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 性医学性医学性医学性医学
背景情况:
- 性功能障碍 (SD) 是癌症患者经常关注的问题,但在接受免疫检查点抑制剂 (ICI) 的人群中,其患病率和预测因素尚未确定.
- 在这个特定的患者群体中了解SD对于全面的癌症护理至关重要.
研究的目的:
- 确定使用免疫检查点抑制剂 (ICI) 治疗的患者中性功能障碍的患病率.
- 在这个患者队列中确定与性功能障碍相关的人口和临床预测因素.
主要方法:
- 一项涉及208名成年癌症患者的横截面研究,这些患者接受了至少三轮ICI,并且性活跃.
- 经过验证的仪器,包括亚利桑那州性经验量表 (ASEX) 和Golombok-Rust性满意度目录 (GRISS),用于评估性功能.
- 进行了后勤回归分析,以确定SD的预测因素.
主要成果:
- SD的患病率很高,ASEX为66.3%,GRISS为59.1%.
- 多变量分析显示,60岁或以上的年龄,女性性别,ECOG表现状况≥1,≥2转移部位和后期治疗线是SD的独立预测因素 (ASEX).
- 使用GRISS确定了可比的预测因素,突出了ECOG状态和转移性负担.
结论:
- 性功能障碍在接受免疫检查点抑制剂治疗的患者中非常普遍,影响了近三分之二的个人.
- SD的关键决定因素包括女性性别,晚年,表现不佳的状态,更高的转移性负担和后期的治疗线.
- 对于接受ICI的患者来说,定期进行性健康评估是必不可少的,以解决癌症存活率的这一重要方面.
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