相关实验视频

Updated: Jan 10, 2026

Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies

Sample Preparation of Mycobacterium tuberculosis Extracts for Nuclear Magnetic Resonance Metabolomic Studies

Published on: September 3, 2012

潜在的生物标志物和Mycoplasma synoviae感染的潜在致病性:从代谢学分析的见解

Xiaona Wei^1,2, Mengyao Sun¹, Kuan Zhang¹

¹School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.

|November 27, 2025

概括

细胞突变菌 (MS) 感染显著改变的新陈代谢,特别是氨基酸,核酸和脂质通路. 特定的代谢物与疾病严重程度相关,为禽类病原体相互作用提供了洞察力.

科学领域:

兽医科学兽医科学兽医科学
代谢学代谢学代谢学
禽类的健康禽类的健康

背景情况:

质菌 (Mycoplasma synoviae) (MS) 是一个重要的家禽病原体,造成经济损失.
了解宿主-MS相互作用和感染的代谢基础需要进一步的研究.

研究的目的:

在感染不同毒性菌株Mycoplasma synoviae后,识别的代谢变化.
探索宿主代谢变化,疾病严重程度和MS病原性之间的关系.

主要方法:

来自感染致命性 (ZX313) 和低毒性 (SD2) MS 菌株的SPF 的血的非向代谢学分析.
鉴定和分析显著差异丰富的代谢物 (SDMs) 和它们相关的代谢途径.
血代谢物与疾病严重程度之间的相关性分析.

主要成果:

感染两种MS菌株导致宿主氨基酸,核酸和脂质代谢发生显著变化.
在ZX313和SD2感染组之间观察到不同的SDM.
20种血代谢物与疾病严重程度有很强的相关性 (AUC = 0.986).

结论:

在中,Mycoplasma synoviae感染对系统性宿主代谢产生了深远的影响.
不同的代谢反应,特别是氨基酸途径,可能与MS病毒性和疾病进展有关.
已识别的代谢物作为评估感染严重程度和了解宿主-病原体动态的潜在生物标志物.

关键词:

菌质突突 (Mycoplasma synoviae) 是一个突突.病变的发生和发病.有显著差异丰富的代谢物.没有目标的代谢学.毒性毒性是一种毒性.

更多相关视频

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

相关概念视频

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

Overview of Protein Metabolism

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

MALDI-TOF Mass Spectrometry

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...