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乙型肝炎病毒相关的肝病和肠道微生物群:一个最新的评论
Duoduo Lv1,2,3, Ning Han1,2,3, Huan Liu1
1Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
Microorganisms
|November 27, 2025
概括
肠道微生物群的改变与肝脏疾病的进展有关. 本综述探讨了肠肝轴,乙型肝炎病毒 (HBV) 感染以及慢性HBV患者的微生物向疗法.
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群影响宿主的新陈代谢,免疫力和能量平衡.
- 肠-肝轴描述了肠和肝之间的双向通信.
- 肠道微生物群失生症越来越多地与肝脏疾病的发病有关.
研究的目的:
- 审查肠道微生物群和微生物群-肠-肝脏轴在肝脏健康和疾病中的作用.
- 检查乙型肝炎病毒 (HBV) 感染与肠道微生物群之间的相互作用.
- 讨论HBV相关肝脏疾病中的微生物群失生症,并探索潜在的微生物群向疗法.
主要方法:
- 临床和实验研究的文献综述.
- 分析肠道微生物群在HBV感染和肝病进展中的作用.
- 针对肠道微生物群的治疗策略的评估.
主要成果:
- 微生物群失生症是HBV相关肝脏疾病的发病的一个重要因素,包括慢性HBV感染,肝硬化和肝细胞癌.
- 增加的肠道透性允许细菌产品进入肝脏,通过肠肝轴影响疾病的进展.
- 针对微生物群的疗法,如益生菌和便微生物群移植,显示出管理与HBV相关的肝病的潜力.
结论:
- 肠道微生物群在与HBV相关的肝病中起着至关重要的作用.
- 了解微生物群-肠道-肝脏轴提供了对疾病机制的见解.
- 基于微生物群的疗法对慢性乙型肝炎 (CHB) 患者的个性化治疗策略有前途.
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