利用基于地表水的多面性方法对抗动物病病毒:来自孟加拉国和中国的农村视角
Yizhe Wu1, Yuqing Long2, Xueling Yang3
1School of Life Science, Northwest University, Xi'an 710069, China.
Microorganisms
|November 27, 2025
概括
在缺乏传统废水系统的热带地区,地表水监测有效地检测到禽流感病毒 (AIV) 和登革热病毒. 将AIV监测与鸟类采样和登革热监测与网络搜索数据相结合,可提供低成本的预警系统.
科学领域:
- 环境微生物学环境微生物学
- 病毒学 病毒学
- 数字流行病学数字流行病学
背景情况:
- 热带农村地区面临着越来越多的动物性疾病威胁,如禽流感病毒 (AIV) 和登革热病毒.
- 这些地区的基础设施有限,阻碍了传统的废水监测方法.
研究的目的:
- 在资源有限的热带环境中对艾滋病毒和登革热病毒实施和评估基于地表水的监测 (SWBS).
- 将SWBS与数字流行病学工具集成,包括机器学习和网络搜索数据,以增强预警能力.
主要方法:
- 用RT-qPCR分析了地表水样本,用于AIV和登革热病毒检测.
- 野生鸟类便被收集用于AIV源追踪,并对两种病毒进行基因组测序.
- 登革热监测通过使用机器学习模型分析与登革热症状相关的网络搜索查询量来增强.
主要成果:
- 在地表水中检测到AIV H5和登革热病毒,与临床趋势相关.
- 表面水的病毒载荷变化大约在两周之前临床登革热报告.
- 使用网络搜索数据的机器学习模型解释了登革热RNA水平的79%的差异,减少了35%的采样需求.
结论:
- 在基础设施有限的地区,SWBS是传染病监测的可行替代方案.
- 将AIV SWBS与野生鸟类采样相结合有助于来源归因.
- 将登革热SWBS与实时网络搜索监控相结合,为热带地区提供了一种高效,低成本的预警系统.
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