来自地下真菌的Norditerpene天然产品具有抗寄生虫活性
Alexandra Kolas1, Yudi Rusman2, Ana C R G Maia1
1Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, USA.
Microorganisms
|November 27, 2025
概括
地下真菌的天然产品为对抗导致腹疾病的寄生虫Cryptosporidium提供了新的希望. 乙甲和乙具有强大的抗寄生虫活性,具有低毒性,为新疗法铺平了道路.
科学领域:
- 自然产品 化学 化学
- 寄生虫学的寄生虫学
- 药物发现 药物发现 药物发现
背景情况:
- 克里普托斯波里是一种重要的由水传播的病原体,导致全球性腹疾病.
- 目前对密码化症的治疗方法缺乏有效的治疗选择.
研究的目的:
- 为了选天然产品的抗Cryptosporidium活性.
- 识别和描述来自地下真菌的新型抗寄生虫化合物.
主要方法:
- 从地下环境中选的真菌和细菌提取物.
- 从Oidiodendron truncatum中分离和阐明活性北烯乳的结构.
- 对抗寄生虫活性 (EC50) 和对Cryptosporidium parvum和Toxoplasma gondii的细胞毒性的确定.
- 在IFNγ-/-小鼠体内疗效研究.
主要成果:
- 来自Oidiodendron truncatum的七种北烯乳显示出强大的抗Cryptosporidium活性.
- 乙甲和乙呈现出高强度 (EC50分别为530nM和240nM),没有宿主细胞细胞毒性.
- 奥伊迪奥拉克A对C. parvum无性阶段表现出活性,在体内减少了70%的感染,并表现出快速杀死寄生虫.
- 还观察到对相关的寄生虫Toxoplasma gondii的活性.
结论:
- 乙甲和乙是强大的抗菌剂,具有良好的安全性.
- 这些化合物代表了开发新疗法对抗密码菌病的有希望的支架.
- 奥伊迪奥拉克顿的天然来源,效力,低毒性和可访问性支持其进一步发展.
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