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合成,表征和初步抗菌评价的奇托-4-阿尼沙尔合物结合物

Danelya N Makhayeva¹, Dayana D Mukhamediya¹, Saiyara R Tairova¹

¹Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.

|November 27, 2025

概括

功能性酸盐衍生物 (ChT-AA) 被合成并形成凝. 虽然在溶液中显示出适度的抗微生物活性,但由于扩散受限,它们在凝形式的有效性是有限的.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
生物材料工程生物材料工程

背景情况:

对于有效的抗微生物聚合物材料的需求日益增加.
基托桑衍生物提供了增强的物理化学和生物特性.
需要功能化奇托桑,提高抗菌性能.

研究的目的:

合成奇托-4-化联合体 (ChT-AA).
描述合成的ChT-AA的结构和热性质.
评估基于ChT-AA的凝的风湿学和抗菌性能.

主要方法:

用于ChT-AA合成的希夫基形成.
FT-IR,1小时NMR,TGA/DSC用于表征.
风湿学研究和磁盘扩散试验用于凝评估.
在液体介质中确定最小抑制度 (MIC).

主要成果:

成功合成和表征ChT-AA与imine链接.
与原生奇多相比,ChT-AA表现出增强的热稳定性和刚性.
ChT-AA凝显示了非牛顿式剪切稀释行为和粗性.
在液体介质中,ChT-AA显示出对黄金色细菌的增强活性;凝具有有限的抗菌活性.

结论:

基托桑与4-anisaldehyde的功能化增强了热稳定性和刚性.
ChT-AA显示出对溶液中黄金色杆菌的抗微生物活性得到改善.
由于扩散限制,ChT-AA的抗菌疗效在凝形式显著降低.

关键词:

4 - 化-4-化舰队的基础形成是船的基础.它具有抗微生物特性.基多酸盐的使用方法凝是一种凝.

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