甲酸盐的毒性:基于流行病学和毒理学证据的审查
Yuehang Wei1, Minghui Zhang1, Jiayuan Song1
1Department of Nutrition and Food Hygiene, Suzhou Medical College, Soochow University, Suzhou 215123, China.
Toxics
|November 27, 2025
概括
酸盐暴露与儿童的损伤有关,但成人数据不清楚. 这篇评论详细介绍了酸盐如何通过氧化应激和纤维化等机制对脏造成伤害.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 酸盐是常见的塑化剂,具有已知的健康风险.
- 现有的审查涵盖了多器官毒性,但缺乏对损伤 (毒性) 的关注.
- 由于广泛暴露,了解甲酸盐毒性至关重要.
研究的目的:
- 综合审查关于甲酸盐脏毒性的流行病学和毒理学证据.
- 探索甲酸引起的损伤背后的机制.
- 为了确定未来的甲酸盐毒性研究需求.
主要方法:
- 对甲酸盐暴露和功能标志物的流行病学研究进行系统审查 (白蛋白与肌素的比率[ACR],淋巴细胞过率[eGFR]).
- 对毒理学数据的分析,以阐明甲酸盐毒性机制.
- 综合当前的知识,提出未来的研究方向.
主要成果:
- 流行病学研究表明,甲酸盐暴露与儿童的异常ACR和eGFR相关.
- 证据表明,酸盐与成年人ACR/eGFR异常之间的联系目前存在争议,需要更多的研究.
- 已识别的机制包括氧化应激,降低阿尔多素,氨酸- ангиотензин系统调节失调,ER应激,纤维化,阻断恒温和热冲击反应激活.
结论:
- 酸盐对脏健康构成重大风险,特别是在儿童中.
- 进一步的研究是必不可少的,以澄清酸盐对成人功能的影响.
- 阐明特定的机制可以为预防法甲酸盐引起的毒性制定预防策略.
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