来自墨西哥半沙漠植物的输液提取物的封装和消化评估:植物化学分析和生物活性
Antonio Julián-Flores1, Mariela R Michel2, Cristóbal N Aguilar1
1Bioprocesses & Bioproducts Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, Coahuila, Mexico.
这项研究评估了墨西哥药用植物的胃肠道疾病. 佛拉登德朗 (Phoradendron californicum) 显示出强烈的抗氧化活性,而Artemisia ludoviciana则表现出强大的抗寄生虫作用.
科学领域:
- 民族植物学和植物化学.
- 药理学和自然产品的研究.
背景情况:
- 由于生物活性化合物,药用植物在传统医学中至关重要.
- 三种墨西哥半沙漠物种Flourensia cernua,Artemisia ludoviciana和Phoradendron californicum用于胃肠道问题.
研究的目的:
- 分析这些植物的化学成分,提取,植物化学特征,抗氧化,抗寄生虫和抗菌活性.
- 评估封装在模拟消化过程中保护提取物完整性的有效性.
主要方法:
- 高性能液体染色学-质谱学 (HPLC-MS) 用于表征.
- 在体外模拟消化和抗氧化剂测定 (DPPH,ABTS).
- 对大肠杆菌和黄金杆菌的抗寄生虫和抗菌活性评估.
主要成果:
- A. ludoviciana的素含量最高;F. cernua的黄素度最高.
- 美国的P. californicum表现出最强的抗氧化活性 (DPPH: IC50 74.18 μg/mL; ABTS: IC50 333.38 μg/mL).
- A. ludoviciana表现出显著的抗寄生素活性 (IC50 0.51 mg/mL),而F. cernua则表现出对大肠杆菌和金黄色杆菌的强有力的抗菌作用.
结论:
- P. californicum是一种强大的抗氧化剂来源,而A. ludoviciana具有强大的抗寄生素特性.
- F. cernua 具有显著的抗菌活性.
- 封装有效地保持了植物提取物的完整性,在模拟消化过程中,可水解的色素最多会释放出来.
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