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通过UPLC-HRMS和分子对接,从巴西药用植物中寻找低血糖化合物
Elisabeth Mariano Batista1, Gabriela Araújo Freire2, Caio Bruno Rodrigues Martins2
1Programa de Pós-Graduação em Ciência e Tecnologia de Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal do Ceará, Campus Pici, Fortaleza 60356-000, CE, Brazil.
巴西的药用植物在治疗2型糖尿病方面表现有前途. 来自Lippia origanoides,Amburana cearensis和 Justicia pectoralis的提取物显示出显著的α-葡萄糖酶抑制,这表明它们有可能作为天然抗糖尿病剂.
科学领域:
- 药理学和植物化学
- 自然产品化学 自然产品化学
背景情况:
- 2型糖尿病是一种严重的全球健康问题.
- 对于管理高血糖的天然化合物越来越感兴趣.
研究的目的:
- 评估来自巴西五种药用植物的水性提取物的低血糖潜力.
- 识别活性化合物并评估它们的安全性,用于开发植物性抗糖尿病药物.
主要方法:
- 五种巴西植物的水性提取物被选为α-葡萄糖酶和肠道分糖酶抑制.
- 使用UPLC-HRMS.MS进行化学分析.
- 进行了分子对接,体外酶抑制试验,ADME模拟和斑马鱼急性毒性试验.
主要成果:
- 利皮亚原,Amburana cearensis和Justicia pectoralis的提取物显示出强大的α-葡萄糖酶抑制活性.
- 黄酸,化物和肉酸衍生物,酸和氨酸被确定为关键活性成分.
- 与阿卡尔相比,异quercitrin 显示出更强的α-葡萄糖酶抑制,对L. origanoides和A. cearensis的安全性概况有利.
结论:
- 利皮亚原,Amburana cearensis和Justicia pectoralis是天然低血糖化合物的有希望的来源.
- 异quercitrin是一种强大的α-葡萄糖酶抑制剂,具有治疗2型糖尿病的潜力.
- 这些植物物种为开发安全有效的植物抗糖尿病疗法提供了基础.
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