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富含厄戈斯特的脂质体与加工后的修改为Serpylli草药多提供:物理化学,稳定性和抗氧化剂评估

Aleksandra A Jovanović¹, Predrag Petrović², Andrea Pirković¹

¹Institute for the Application, Nuclear Energy INEP, University of Belgrade, 11000 Belgrade, Serbia.

|November 27, 2025

概括

欧戈斯特醇增强了脂质体的稳定性和生物活性化合物的封装效率,提供了适合素食主义者的替代品. 较高的厄戈斯特醇含量提高了抗氧化剂的保留和抗UV和冷干燥压力的弹性.

科学领域:

生物材料科学生物材料科学
制药技术制药技术制药技术
自然产品化学自然产品化学

背景情况:

埃尔戈斯特,一种由真菌衍生的固醇,为脂质体配方提供了一种新的,无动物替代胆固醇的替代品.
它的天然来源与对制药和营养产品中可持续,适合素食者的成分日益增长的需求相一致.

研究的目的:

为了研究不同度的ergosterol (10mol%对20mol%) 对Serpylli草本提取物装载脂质体的特性的影响.
评估埃尔戈斯特对封装效率,物理特性,抗氧化活性和储存稳定性的影响.

主要方法:

装有Serpylli草本提取物的脂质体被用不同的ergosterolmol%制备.
评估了封装效率 (EE),粒子大小,泽塔潜力,形态 (TEM),抗氧化活性 (ABTS,FRAP),脂质过氧化 (TBARS) 和在各种压力条件下 (UV,冷干燥) 的储存稳定性.

主要成果:

与20mol%的ergosterol相比,20mol%的脂质体显示出更高的EE (~81.0%) 和更好的抗UV和冷干燥应激相比,10mol%.
在储存期间,更高的厄戈斯特含量增强了囊泡的均性,体稳定性和完整性,对囊泡度有剂量依赖的影响.
富含厄戈斯特的脂质体表现出受控的多释放和保存的抗氧化活性,提取物减轻了UV诱导的脂质过氧化.

结论:

增加的厄戈斯特醇含量显著改善脂质体性能,包括封装,结构弹性和抗氧化剂保留,特别是在压力下.
基于ergosterol的脂质体提供了增强的稳定性,有利的颗粒大小和高EE,保持了封装提取物的生物活性.
这些发现支持ergosterol脂质体作为有前途的,可持续的载体,用于制药和营养药的应用.

关键词:

塞尔皮利草 (Serpylli herba) 是一种植物.埃尔戈斯醇 (Ergosterol) 是一种脂质体是一种脂质体.多抗氧化剂是一种多抗氧化剂.类风病学类风病学类风病学稳定的稳定性稳定的稳定性

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