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Updated: Jan 10, 2026

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在FDA监管审查中,PBPK建模的演变和未来方向

Yangkexin Li1, Henry Sun1, Zuoli Zhang1

  • 1SunTech Research Institute, LLC., Rockville, MD 20850, USA.

Pharmaceutics
|November 27, 2025
PubMed
概括

基于生理学上的药理动力学 (PBPK) 模型在药物开发中越来越重要,支持超过26%的新药的监管提交. 这些模型在预测药物相互作用和指导剂量策略方面具有重要价值.

关键词:
在PBPK模型中,人工智能的人工智能是人工智能.药物药物相互作用 (DDI)基于生理学的药物动力学.监管科学是一种监管科学.

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