口服营养补充剂对胃肠道癌症患者的影响:一项随机对照试验
Rania M Sarhan1, Marian S Boshra1, Al Shaimaa Ibrahim Rabie2,3
1Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62521, Egypt.
口服营养补充剂在接受化疗的胃肠癌患者中改善了体重和脂肪质量. 早期补充改善了营养状况,保持了身体组成,支持了治疗的坚持.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 营养不良是一个全球性的健康挑战,在胃肠道 (GIT) 癌症患者的化疗中加剧了.
- 化疗可以对营养状况和生活质量产生负面影响.
- 解决营养不良问题对于可持续发展目标和患者福祉至关重要.
研究的目的:
- 评估口服营养补充剂 (ONS) 对接受化疗的关节结肠癌患者营养状况的影响.
- 评估ONS对全身构成和患者报告结果的影响.
- 确定ONS是否可以减轻化疗引起的营养不良,并支持治疗.
主要方法:
- 一项为期12周的研究比较了一组营养支持 (NS) 组 (n=75),接受500千卡/天ONS,与一组控制 (C) 组 (n=75),没有ONS.
- 评估人体测量,全身成分 (骨质量,脂肪质量),营养生物标志物 (白蛋白,总蛋白质) 和患者生成的主观总体评估 (PG-SGA).
- 分析了脂质特征,不良反应和治疗延迟.
主要成果:
- 与C组相比,NS组的体重和脂肪量显著增加.
- 在群体之间观察到脂肪质量指数 (FMI) 和瘦肉质量指数的统计学上显著差异,有利于NS组.
- 在NS组中,PG-SGA得分和白蛋白水平的改善被注意到.
结论:
- 早期开始服用口服营养补充剂可以显著改善化疗中GIT癌症患者的营养状况.
- 在治疗期间,ONS可能有助于保持身体组成,包括脂肪和瘦肉量.
- 补充可能会减少治疗延迟,并改善患者的整体结果.
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