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纳米粒子介导的鼻至脑输送用于缺血性中风治疗:临床前见解

Joonhyuck Park^1,2, Tae-Ryong Riew^2,3

¹Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

|November 27, 2025

概括

内鼻分娩提供了一种非侵入性的方法,通过绕过血脑屏障来治疗缺血性中风. 这种方法增强了药物输送用于神经保护和再生,改善功能恢复.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

缺血性中风导致显著的死亡率和残疾.
像血栓溶解这样的当前疗法也有局限性,包括狭窄的治疗窗口和血脑屏障 (BBB) 限制药物获取.
内鼻 (IN) 交付为克服这些挑战提供了一个有希望的替代方案.

研究的目的:

审查最近的临床前进展,用于缺血性中风的鼻内疗法.
突出纳米技术在增强IN药物输送中的作用.
探索IN输送在神经保护和功能恢复方面的潜力.

主要方法:

对缺血性中风的IN疗法进行临床前研究的审查.
专注于各种治疗剂:小分子,生物制剂,核酸和基于细胞的疗法.
重点是纳米技术应用:细胞外囊泡,脂质体和无机纳米粒子.

主要成果:

IN 交付有效地绕过了 BBB,提供了快速的 CNS 访问.
纳米技术提高了IN疗法的稳定性,向性和生物可用性.
输送生长因子,细胞因子和干细胞促进神经发生,血管发生和白质修复,从而导致功能恢复.

结论:

鼻内输送是治疗缺血性中风的有希望的非侵入性策略.
它克服了传统疗法的局限性,通过有效的神经保护和再生.
需要进一步的研究,以获得IN治疗中风的临床转化.

关键词:

血脑屏障是什么意思药物通过鼻内注射输送.缺血性中风中风纳米材料是一种纳米材料.从鼻子到大脑的运输.

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