相关实验视频

Updated: Jan 10, 2026

Candida albicans Biofilm Chip CaBChip for High-throughput Antifungal Drug Screening

Candida albicans Biofilm Chip CaBChip for High-throughput Antifungal Drug Screening

Published on: July 18, 2012

一个赫西丁纳米载体策略来对抗口腔候群病微观宇宙生物膜

Leandro Pimentel Cabral¹, Juliano Pelim Pessan¹, Caio Sampaio¹

¹Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil.

Pharmaceuticals (Basel, Switzerland)

|November 27, 2025

概括

携带赫西丁 (CHX) 的氧化铁纳米颗粒有效降低了口腔候群病生物膜. 这种纳米疗法在传统CHX度的一半时实现了显著的抗菌膜效应,为治疗口腔感染提供了有前途的策略.

科学领域:

在牙科的纳米技术.
抗菌生物材料抗菌生物材料
口腔微生物学口腔微生物学

背景情况:

坎迪达菌耐药性需要新的治疗策略,如纳米疗法.
口腔候群病涉及复杂的微观生物膜,需要有效的治疗.
铁氧化物纳米粒子 (IONPs) 与素 (CS) 功能化,可以作为药物载体.

研究的目的:

为了评估含有赫西丁 (CHX) 的IONPs-CS纳米载体的抗菌膜疗效.
评估IONPs-CS-CHX对口腔候群病菌微观生物膜的影响.
为了比较纳米载体输送的CHX与自由CHX的有效性.

主要方法:

通过使用健康的捐赠者唾液和Candida物种,建立了口腔候群病微观生物膜.
生物膜被IONPs-CS加载CHX (IONPs-CS-CHX78,IONPs-CS-CHX156) 处理了24小时. 这些生物膜被IONPs-CS加载CHX (IONPs-CS-CHX78,IONPs-CS-CHX156) 处理了24小时.
测试包括生物质,新陈代谢,微生物负荷,乳酸生产和对生命力和结构的共聚焦显微镜.

主要成果:

IONPs-CS-CHX156在测试的生物膜中显示了代谢,微生物负载和生存能力的显著减少.
与对照组相比,纳米载体在口腔候群病生物膜中显著增加了乳酸水平.
在所有生物膜模型中,CHX和IONPs-CS-CHX156是最有效的药物.

结论:

IONPs-CS纳米载体有效地输送了CHX,使口腔 кандидоз生物膜减少了自由CHX度的一半.
这种纳米结构显示出开发用于口腔候群病管理的先进杀菌剂和消毒剂解决方案的潜力.
这种纳米载体系统的进一步探索对于口腔健康的临床应用是有必要的.

关键词:

生物膜是一种生物膜.基多酸盐的使用方法氧化的含量是多少铁氧化物纳米粒子铁氧化物纳米粒子在口服中,有口腔候群.

更多相关视频

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

Daily Phototherapy with Red Light to Regulate Candida albicans Biofilm Growth

Daily Phototherapy with Red Light to Regulate Candida albicans Biofilm Growth

Published on: April 23, 2019

相关概念视频

Hand hygiene

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...

Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...